If the are going to cover the spread against the this week, they're going to have to turn the game into a rout because oddsmakers have hit New England with the largest point spread in three years. Week 16 The Patriots have officially opened as a 16.5 point favorite over the Jets, which is the highest point spread of the season, and the highest point spread in any NFL game since October 2013, when the over the . This is the kind of point spread you get when Vegas keeps losing money on a team, and they keep losing money on the Marcus Camby Jersey Patriots. New England is 11-3 against the spread this year, making them the safest NFL bet of 2016. Of course, the ugline s of the Jets season also plays into the large point spread. Their starting quarterback ( ) is banged up and their backup quarterback ( ) throws interceptions like it's his job. Betting a spread this big is never easy, however, history seems to favor the underdog. According , in the past 20 instances where a team has been favored by 16 or more points, the underdog has gone 14-5-1 against the spread. The Jaguars of 2013 were one of the teams that ended up covering. As a 26.5 point underdog, the Jags ended up losing by "just" 16 (35-19). The Jets-Patriots game will mark the ninth time in the Brady-Belichick era that the Patriots have been favored by 16 or more points. In those nine games, the Patriots are 9-0 straight-up, but just 3-6 against the spread. If there is one sure bet here, it's betting on the Patriots to win. Since 1990, there have been 59 teams that have been favored by 16 or more points and those teams have gone 56-3 straight-up. The last time a team lost in this scenario came in 1995 when the Terence Davis Jersey 17-point underdog beat the 24-17. If you take out the Patriots game, the next biggest spread in Week 16 is just 7.5 points. Let's get to the odds. (10-4) at (5-9), Thursday Opening line: Giants, -3 pointsCurrent line: Giants, -3 points With a win over the Eagles on Thursday, the Giants will clinch their first playoff spot since 2011. However, beating Philly won't be easy. The Giants have lost four of their past five to the Eagles and are just 1-3 in their past four trips to Philadelphia. These two teams met back in Week 9 with the Giants winning 28-23 in game where they were also favored by three points. When it comes to covering the spread, the Eagles have struggled against divisional opponents, going just 3-7 since the beginning of 2015, which is tied with Carolina as the worst mark in the NFC over that span. Redskins (7-5-1) at (3-11) Opening line: Redskins, -4 pointsCurrent line: Redskins, -3.5 points Somehow, has become the safest bet in the NFL. In Barkley's three starts this season, the Bears are 3-0 ATS (1-2 straight-up), which isn't even the most impre sive thing about Chicago. The most impre sive thing is that the Bears have covered five games in a row. In this game, they'll be getting a Redskins team that has to fly halfway acro s the country after a Monday night game, which is notable because Washington only has four days between games since this is being played on Saturday. Before you go betting the Bears though, just keep in mind that they're 0-6 straight-up in their past six meetings against the Redskins and haven't beaten them since 2003. (9-5) at (7-7) Opening line: Bills, -3.5 pointsCurrent line: Bills, -3.5 points After a warm-up game against Vince Carter Jersey the horrible Jets, new Dolphins starting quarterback will get a tougher test this week when Miami travels to a place where not even has ever won: Buffalo. The Bills have won five of the past seven in this series, including the past four in Buffalo. The Dolphins did win and cover 2.5 point spread with a 28-25 win in Week 7, but that was in South Florida. Miami is 3-1 ATS in divisional games this year, which is the second best mark in the AFC. The Bills are 1-3 ATS in divisional games, which is one of the worst marks in the NFL. (8-6) at (6-8) Opening line: Saints, -3.5 pointsCurrent line: Saints, -3.5 points These two teams just met on Dec. 11, so they should be pretty familiar with each other. In that game, the Bucs defense absolutely shut down in a 16-11 win where Tampa covered (-2 points). The Bucs have been one of the hottest teams in football over the past six weeks, going 5-1 straight-up and an even better 6-0 ATS. The Bucs won't be afraid of the Superdome, either, because they won there last season (26-19). Although the Saints have been inconsistent this season, they have been pretty consistent in divisional games over the past two years. Since the beginning of 2015, New Orleans is 7-3 ATS in divisional games, which is the second best mark in the NFC over that span. (9-5) at (5-8) Opening line: Falcons, -3.5 pointsCurrent line: Falcons, -3.5 points The Falcons have exploded for more than 40 points in each of the past two weeks, and they've done that without in the lineup. There's a chance that Jones could be back for this game, which would make Atlanta's offense even more lethal. With Jones in the lineup, the Falcons dropped 48 on the Panthers back in a Week 4 win (48-33) where Atlanta was a two-point underdog. Although the Chauncey Billups Jersey Falcons have won two in a row against the Panthers, they've lost three of their past four in Charlotte. Since the beginning of 2015, the Panthers are just 3-7 ATS in divisional games, which is the second worst mark in the NFC over the span. (7-7) at (8-6) Opening line: Packers, -6.5 pointsCurrent line: Packers, -7 points The Packers haven't been great this season ATS (7-6-1), but they have been pretty good when they're a heavy favorite. In five games this season where the Packers have been a favorite of six or more points, they're 3-1-1 ATS and 4-1 straight-up. If you're thinking about betting the Vikings, do so at your own risk: Minnesota is 2-7 ATS in their past nine games. On the other hand, the Vikings have done a good job of covering as a road underdog recently. Since the beginning of 2015, Minnesota is 7-2 as a road dog, which is the third best mark in the NFL over that span. When these two teams played in Week 2, the 1.5 point favorite Packers lost 17-14. Jets (4-10) at Patriots (12-2) Opening line: Malachi Flynn Jersey Patriots, -16.5 pointsCurrent line: Patriots, -16.5 points If this line holds, then we'll be getting our biggest spread of the year on Saturday with the Patriots favored by a ridiculous 16.5 points. Of course, a lot of that has to do with the fact that New York will either be starting Bryce Petty or turnover machine Ryan Fitzpatrick at quarterback. Petty got hurt in Week 15, and if he can't go on Saturday, then Fitzpatrick will start. Although