It's a big one for the Indianapolis Colts on Sunday.After tying in a very winnable matchup last week, the Colts (0-0-1) head south to a locale that has been unkind to them in the past; the Jacksonville Jaguars' (0-1) TIAA Bank Field.The Colts haven Dellin Betances Jersey 't won there since a 44-17 blowout in Week 3 of 2014. In their seven attempts since(2016's game was in London), they've been outscored 208-104.Here is everything you need to know about matchup.Date/Time: Sunday, Sept. 18, at 1:00pm ETWhere: Jacksonville, Fla.; TIAA Bank FieldTelevision: CBS Tom McCarthy (play-by-play), Tiki Barber (color)Stream: To find out what games will be on in your area on Sunday, Radio: WFNI 1070-AM The Fan, WLHK 97.1 HANK FM Matt Taylor (play-by-play), Rick Venturi (color), Larra Overton (sideline)On-Demand: NFL+ (after the fact)ALL-TIME SERIESColts lead, 26-16. The two teams have split their annual matchups each season back through 2018.Last game: Week 18 of 2021; Jaguars won, 26-11.COACHESColts: head coach Frank Reich; offensive coordinator Marcus Brady; defensive coordinator Gus Bradley; special teams Bubba Ventrone.Jaguars: head coach Doug Pederson; offensive coordinator Pre s Taylor; defensive coordinator Mike Caldwell; special teams Heath FarwellColtsOUT LB Shaquille Leonard (back), WR Alec Pierce (concu sion), WR Michael Pittman Jr. (quad)QUESTIONABLE DT DeForest Buckner (hip), Kenny Moore II (hip)JaguarsNo injuriesSTORYLINES/THINGS TO WATCHKill the streak: Simply put, the Colts need to beat the Jaguars for two big reasons. First, falling to 0-1-1 with matchups against the Kansas City Chiefs, Tenne see Titans, and Denver Broncos upcoming has the potential to put them in a big hole. Second, losing in Jacksonville has officially become a thing. Winning on Sunday removes the stigma from this matchup each year.End the mistakes: The Colts looked like the better team last week against the Houston Texans but ultimately tied, 20-20. The difference between winning and losing (or a draw) was all the self-inflicted wounds. The Colts fumbled five times, with two turnovers, and had some untimely penalties. They also had some breakdowns in coverage that resulted in two scores, and dropped two potential touchdowns. The Colts could have easily Gio Gonzalez Jersey won last week by double digits but shot themselves in the foot too many times.Important injuries: The Colts already ruled out Pierce and Leonard, and three more starters are questionable in Pittman, Buckner, and Moore. The Colts could be down two of their top three receivers, which puts Parris Campbell, Ashton Dulin, and Mike Strachan in the spotlight. Look out for a favorable matchup for Campbell. If Buckner mi ses the game, the Colts may continue to lack a rotation on the defensive line. Moore performing injured against an effective Jaguars receiving corps, or mi sing the game altogether, could be troublesome.Running backs have bigger impact as pa s-catchers?: The Jaguars will no doubt be prepared to attempt to stop Colts running back Jonathan Taylor. If they did, it wouldn't be the end of the world because Taylor and Nyheim Hines both are dangerous as pa s-catchers. The pair caught 10 balls last week, and the Jaguars allowed Washington Commanders running backs Antonio Gibson and J.D. McKi sic to catch 10 as well in Week 1. The Colts can take advantage of Jacksonville's bigger linebackers by using their running backs' speed on the outside.INTRIGUING MATCHUPSColts RT Braden Smith vs. Jaguars ED Josh Allen: Smith had a rough go of it last week against Texans edge defender Jerry Hughes, posting the NFL's worst pa s-blocking grade among starting offensive Bernie Williams Jersey tackles (46.0), per . He's got another tough matchup this week against the athletic, explosive Allen. The Colts need Smith to rebound in a big way.Colts DE Yannick Ngakoue vs. Jaguars LT Cam Robinson: Ngakoue is one of the NFL's most consistent pa s rushers over the last several years but he put up one of the worst pa s-rushing grades last week (52.9) against Laremy Tunsil. Robinson isn't as effective of a pa s protector so it's a big opportunity for Ngakoue to have a productive day against the team that drafted him.PROJECTED WEATHER .Scroll to ContinueREFEREE ASSIGNMENTHead referee: Alex Kemp (9 years). .BETTING LINEOver/Under: 45.5SEASON LEADERSColtsPa sing: QB Matt Ryan (352 yards)Rushing: RB Jonathan Taylor (161 yards)Receiving: WR Michael Pittman Jr. (121 yards)Touchdowns: WR Michael Pittman Jr., RB Jonathan Taylor (1)Tackles: LB Zaire Franklin (8)Sacks: DE Kwity Paye (2.0)Interceptions: N/AJaguarsPa sing: QB Trevor Lawrence (275 yards)Rushing: RB James Robinson (66 yards)Receiving: WR Christian Kirk (117 yards)Touchdowns: RB James Robinson (2)Tackles: LB Devin Lloyd (11)Sacks: ED Travon Walker (1.0)Interceptions: CB Tyson Campbell, ED Travon Walker (1)TEAM STATSColtsTotal offense: 1st (517.0 YPG)Scoring: Tied-17th (20 Johnny Damon Jersey .0 PPG)Pa sing offense: 1st (340.0 YPG)Sacks allowed: Tied-10th (2)Rushing offense: 6th (177.0 YPG)Third down offense: 15th (40.0%)Red zone offense: Tied-21st (40.0%)Total defense: 9th (299.0 YPG)Scoring defense: Tied-11th (20.0 PPG)Pa sing defense: 15th (222.0 YPG)Sacks: Tied-10th (3)Rushing defense: 9th (77.0 YPG)Third down defense: Tied-11th (33.3%)Red zone defense: Tied-24th (100.0%)Turnover differential: Tied-19th (-1)JaguarsTotal offense: 13th (383.0 YPG)Scoring: 14th (22.0 PPG)Pa sing offense: 11th (260.0 YPG)Sacks allowed: Tied-10th (2)Rushing offense: 12th (123.0 YPG)Third down offense: Tied-27th (25.0% Blank Jersey )Red zone offense: Tied-21st (40.0%Total defense: 23rd (390.0 YPG)Scoring defense: 28th (28.0 PPG)Pa sing defense: 29th (305.0 YPG)Sacks: Tied-23rd (1)Rushing defense: 13th (85.0 YPG)Third down defense: 31st (70.0%)Red zone defense: Tied-24th (100.0%Turnover differential: Tied-3rd (+2)NOTESQuarterback Matt Ryan needs four pa s completions to pa s Philip Rivers (5,277) for the sixth-most completions in NFL history. Ryan needs one game-winning drive to pa s Matthew Stafford (42) and tie Brett Favre (43) for the sixth-most in NFL history.Taylor needs one point to pa s Marshall Faulk (198) for the sixth-most points by a Colts player in their first three seasons. Taylor needs seven points to pa s Lenny Moore (204) for the fifth-most points by a Colts player in their first three seasons. Taylor needs two total touchdowns to pa s Moore (34) for the second-most total touchdowns by a Colts player in their first three seasons. Taylor needs one 100-yard rushing game to pa s Faulk (14) for the fourth-most such games in franchise history. Taylor needs one game with 100-plus rushing yards and at least one rushing touchdow